Abstract | UNLABELLED: OBJECTIVE: The effect of this novel margarine on serum lipids and lipoproteins was compared with that of butter in free-living, hypercholesterolemic subjects. DESIGN AND SETTING: A two-period, outpatient cross-over trial at a university hospital lipid clinic. SUBJECTS: The study involved 77 subjects, and was completed by 53 men and 19 women aged 35-65 years with total serum cholesterol levels of between 6.0 and 7.9 mmol/L. INTERVENTION: Two 23-day regimens, separated by a 4-week washout period, included individualised dietary prescriptions supplemented with butter or margarine designed to provide 15% of total dietary energy. RESULTS: In comparison with butter, margarine intake lowered total and LDL-C levels by respectively 11.1% (99% CI: 8.1-14.1) and 11.3% (99% CI: 7.6-15.1). The reduction in LDL-C was < 3% in nearly one-fifth of the subjects despite appropriate changes in serum triglyceride fatty acids. Of the tested clinical and demographic variables, only the percentage of energy obtained from saturated fat during the margarine intake period was associated with dietary responsiveness (explaining 12% of the variation; p < 0.01). CONCLUSION: Our results suggest that a margarine designed to meet nutritional recommendations for hypercholesterolemia is more efficacious than butter in reducing atherogenic lipid levels in hypercholesterolemic subjects.
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Authors | S Tonstad, E C Strøm, C S Bergei, L Ose, B Christophersen |
Journal | Nutrition, metabolism, and cardiovascular diseases : NMCD
(Nutr Metab Cardiovasc Dis)
Vol. 11
Issue 5
Pg. 320-6
(Oct 2001)
ISSN: 0939-4753 [Print] Netherlands |
PMID | 11887429
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoprotein A-I
- Apolipoproteins B
- Cholesterol, HDL
- Cholesterol, LDL
- Dietary Fats
- Fatty Acids
- Triglycerides
- Butter
- Margarine
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Topics |
- Adult
- Aged
- Apolipoprotein A-I
(blood)
- Apolipoproteins B
(blood)
- Butter
(analysis)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Cross-Over Studies
- Dietary Fats
(administration & dosage)
- Fatty Acids
(administration & dosage, blood)
- Female
- Food Technology
- Humans
- Hypercholesterolemia
(diet therapy)
- Male
- Margarine
(analysis)
- Middle Aged
- Triglycerides
(blood)
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