Abstract | OBJECTIVE: METHODS: Wistar rats were used and randomly divided into 10 groups, i.e. normal control, 1 PBH (postburn hour), 3 PBH, 6 PBH, 12 PBH and 24 PBH groups of smoke inhalation injury, 6 PBH and 12 PBH groups with dexamethasone treatment, and 6 PBH and 12 PBH groups with chloroquine treatment. The lung water content (LWC), pulmonary vascular permeability (PVP) and hemorrhagic amount (PHA) were measured. RESULTS: The LWC and PVP (measured by the pulmonary exudation amount of (131)I -- labelled albumin) increased obviously, peaked at 6 PBH and lasted to 24 PBH (P < 0.01) in rats injured by smoke inhalation. In groups treated with chloroquine or dexamethasone, the LWC and PVP were significantly lower at 6 PBH (P < 0.05). Similarly, the PHA in injured group exhibited remarkable, especially at 1 PBH and up to 24 PBH when the value was still higher than that in normal control group (P < 0.01). In groups treated with chloroquine or dexamethasone, PHA abated evidently at 6 PBH (P < 0.01). But there were no significant difference of the indices among groups at 12 PBH. CONCLUSION:
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Authors | T Yang, Z Yang, Q Luo |
Journal | Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
(Zhonghua Shao Shang Za Zhi)
Vol. 16
Issue 3
Pg. 150-2
(Jun 2000)
ISSN: 1009-2587 [Print] China |
PMID | 11876860
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dexamethasone
- Chloroquine
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Topics |
- Animals
- Chloroquine
(therapeutic use)
- Dexamethasone
(therapeutic use)
- Female
- Male
- Pulmonary Edema
(prevention & control)
- Rats
- Rats, Wistar
- Smoke Inhalation Injury
(complications, drug therapy)
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