Type 1 diabetes mellitus and epilepsia partialis continua in a 6-year-old boy with elevated anti-GAD65 antibodies.

A 6-year-old boy presented with epilepsia partialis continua 6 months after diagnosis of type 1 diabetes. Anti-glutamic acid decarboxylase 65 antibodies were found in his serum and cerebrospinal fluid. Anti-epileptic agents did not improve his seizures. High-dose steroids, plasmapheresis, and intravenous immunoglobulin resulted in decreased anti-glutamic acid decarboxylase 65 antibody levels and resolution of his seizures.
AuthorsJennifer A Olson, Donald M Olson, Christy Sandborg, Steven Alexander, Bruce Buckingham
JournalPediatrics (Pediatrics) Vol. 109 Issue 3 Pg. E50 (Mar 2002) ISSN: 1098-4275 [Electronic] United States
PMID11875178 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Autoantibodies
  • Immunoglobulins, Intravenous
  • Isoenzymes
  • Prednisolone
  • Glutamate Decarboxylase
  • glutamate decarboxylase 2
  • Autoantibodies (blood)
  • Brain (pathology)
  • Child
  • Combined Modality Therapy
  • Diabetes Mellitus, Type 1 (immunology)
  • Epilepsia Partialis Continua (immunology, therapy)
  • Glutamate Decarboxylase (immunology)
  • Humans
  • Immunoglobulins, Intravenous (therapeutic use)
  • Isoenzymes (immunology)
  • Male
  • Plasmapheresis
  • Prednisolone (therapeutic use)

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