Local injection of OK-432 in the treatment of ranula: a case report.

Abstract

We treated a 57-year-old woman for ranula. After aspirating the cyst's contents, we administered 0.1 KE/ml of OK-432 via local injection. One month later, the cyst had still persisted, so we repeated the procedure. After 2 weeks, the ranula began to shrink markedly, and at 4 weeks it had almost disappeared. No recurrence of the ranula was observed during the subsequent 1 year of follow-up. Following each injection, the patient developed transient fever and local swelling but no serious complications. Our experience suggests that OK-432 injection is an effective treatment for ranula. However, because this treatment causes the cyst to collapse rather than disappear completely, patients should be regularly monitored over the long term.

• Authors: Ken-ichi Watanabe, Shunichi Tomiyama, Ken Jinnouchi, Hiroshi Nakajima, Toshiaki Yagi
• Journal: Ear, nose, & throat journal (Ear Nose Throat J) Vol. 81 Issue 2 Pg. 97-8 (Feb 2002) ISSN: 0145-5613 [Print] United States
• PMID: 11868482 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Picibanil

Topics

• Antineoplastic Agents (therapeutic use)
• Female
• Humans
• Middle Aged
• Picibanil (therapeutic use)
• Ranula (drug therapy)