Abstract | BACKGROUND/AIMS: METHODS: RESULTS: Patients with ascites showed circulating levels of NPY similar to those of patients without ascites and controls (73+/-4, +/-4 and 68+/-4 pmol/l, respectively; NS). However, patients with HRS had significantly increased levels of NPY with respect to the other groups (110+/-6 pmol/l; P<0.001). NPY levels correlated inversely with renal plasma flow and glomerular filtration rate and directly with norepinephrine. In patients with HRS (n=6) treatment with terlipressin and albumin was associated with a marked improvement in circulatory and renal function and marked suppression of NPY and norepinephrine levels. CONCLUSIONS: Patients with HRS have increased levels of NPY which are related to circulatory dysfunction and SNS activation and may contribute to renal vasoconstriction.
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Authors | Juan Uriz, Pere Ginès, Rolando Ortega, Wladimiro Jiménez, Andrés Cárdenas, Blas Calahorra, Pau Sort, Javier Fernández, Ramón Bataller, Vicente Arroyo, Francisca Rivera, Juan Rodés |
Journal | Journal of hepatology
(J Hepatol)
Vol. 36
Issue 3
Pg. 349-55
(Mar 2002)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 11867178
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuropeptide Y
- Creatinine
- Norepinephrine
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Topics |
- Ascites
(blood)
- Creatinine
(blood)
- Female
- Glomerular Filtration Rate
- Hepatorenal Syndrome
(blood)
- Humans
- Liver Cirrhosis
(blood)
- Liver Function Tests
- Male
- Middle Aged
- Neuropeptide Y
(blood)
- Norepinephrine
(blood)
- Renal Circulation
(physiology)
- Vasoconstriction
(physiology)
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