[A case of advanced hypopharyngeal carcinoma successfully treated with superselective intra-arterial infusion of docetaxel].

Abstract

Docetaxel is an excellent agent with a high antitumor effect for advanced/recurrent head and neck cancer. A 67-year-old male with advanced hypopharyngeal cancer (T3N2bM1: Stage IV) underwent two courses of superselective intra-arterial infusion of docetaxel and intravenous administration of CDDP and 5-FU. Using a coaxial technique, a microcatheter was placed in the feeding artery. Using imaging techniques docetaxel (60 mg/body and 30 mg/body) was infused into the vessels. During chemotherapy the patient received concomitant radiotherapy (50 Gy). MRI after chemoradiation showed a complete response for the primary tumor and a partial response for the neck metastasis. Grade 4 leukopenia and neutropenia and grade 3 pharyngitis/esophagitis were observed during chemoradiotherapy, but these adverse effects abated immediately and were not critical. We conclude that this superselective intra-arterial infusion of docetaxel will be useful and safe for head and neck cancer.

• Authors: Takeshi Akisada, Tamotsu Harada, Takuji Takemoto, Kazuyasu Fukuda, Norimasa Morita, Teruhito Aihara, Yasumasa Kajihara, Shigeki Imai, Masayuki Gyoten, Yoshinari Imajo, Junichi Hiratsuka
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 29 Issue 2 Pg. 323-8 (Feb 2002) ISSN: 0385-0684 [Print] Japan
• PMID: 11865643 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Taxoids
• Docetaxel
• Paclitaxel
• Cisplatin
• Fluorouracil

Topics

• Aged
• Antineoplastic Agents, Phytogenic (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, radiotherapy)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Docetaxel
• Fluorouracil (administration & dosage)
• Humans
• Hypopharyngeal Neoplasms (drug therapy, radiotherapy)
• Infusions, Intra-Arterial
• Male
• Paclitaxel (administration & dosage, analogs & derivatives)
• Taxoids