Abstract | BACKGROUND: AIM: DESIGN: Single centre, observational study of 30 consecutive pregnancies complicated by hyperemesis and weight loss of >5% of pre-pregnant weight between April 1995 and July 2000. Comparison of birth weight with a contemporaneous control series of women admitted with hyperemesis that was judged insufficiently severe to require steroids. RESULTS: Treatment with prednisolone 10 mg tid rapid resolved nausea and vomiting, allowing discharge in 3 (range 1-6.5) days. Steroid therapy, which was reduced in a stepwise manner, was discontinued at a median gestation of 20 weeks. Maternal weight gain in pregnancy was restored to normal. Median birth weight in the severe, steroid-treated group was 3.33 (range 2.80-3.27) kg vs. 3.27 (range 3.04-3.53) kg in the less severe group. CONCLUSION:
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Authors | P Moran, R Taylor |
Journal | QJM : monthly journal of the Association of Physicians
(QJM)
Vol. 95
Issue 3
Pg. 153-8
(Mar 2002)
ISSN: 1460-2725 [Print] England |
PMID | 11865170
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Glucocorticoids
- Prednisolone
|
Topics |
- Adult
- Birth Weight
(drug effects)
- Drug Administration Schedule
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Hyperemesis Gravidarum
(drug therapy, physiopathology)
- Infant, Newborn
- Patient Selection
- Prednisolone
(therapeutic use)
- Pregnancy
- Pregnancy Outcome
- Severity of Illness Index
- Treatment Outcome
- Weight Loss
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