Abstract | BACKGROUND: METHODS AND RESULTS: The role of PPARalpha in left ventricular growth was investigated in 144 young male British Army recruits undergoing a 10-week physical training program and in 1148 men and women participating in the echocardiographic substudy of the Third Monitoring Trends and Determinants in Cardiovascular Disease (MONICA) Augsburg study. A G/C polymorphism in intron 7 of the PPARalpha gene significantly influenced left ventricular (LV) growth in response to exercise (P=0.009). LV mass increased by 6.7 +/- 1.5 g in G allele homozygotes but was significantly greater in heterozygotes for the C allele (11.8 +/- 1.9 g) and in CC homozygotes (19.4 +/- 4.2 g). Likewise, C allele homozygotes had significantly higher LV mass, which was greater still in hypertensive subjects, and a higher prevalence of LVH in the Third MONICA Augsburg study. CONCLUSIONS: We demonstrate that variation in the PPARalpha gene influences human left ventricular growth in response to exercise and hypertension, indicating that maladaptive cardiac substrate utilization can play a causative role in the pathogenesis of LVH.
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Authors | Yalda Jamshidi, Hugh E Montgomery, Hans-Werner Hense, Saul G Myerson, Ines Pineda Torra, Bart Staels, Michael J World, Angela Doering, Jeanette Erdmann, Christian Hengstenberg, Steve E Humphries, Heribert Schunkert, David M Flavell |
Journal | Circulation
(Circulation)
Vol. 105
Issue 8
Pg. 950-5
(Feb 26 2002)
ISSN: 1524-4539 [Electronic] United States |
PMID | 11864924
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Cytoplasmic and Nuclear
- Transcription Factors
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Topics |
- Adaptation, Physiological
- Adult
- Aged
- DNA Mutational Analysis
- Disease Progression
- Echocardiography
- Electrocardiography
- Exercise
- Female
- Gene Frequency
- Genetic Testing
- Heart Ventricles
(physiopathology)
- Heterozygote
- Homozygote
- Humans
- Hypertension
(complications, physiopathology)
- Hypertrophy, Left Ventricular
(etiology, physiopathology)
- Male
- Middle Aged
- Polymorphism, Genetic
- Receptors, Cytoplasmic and Nuclear
(genetics)
- Risk Assessment
- Transcription Factors
(genetics)
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