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Acute hepatic failure in IFN-gamma-deficient BALB/c mice after murine coronavirus infection.

Abstract
We previously showed that an intraperitoneal infection with mouse hepatitis virus (MHV) persists in interferon-gamma (IFN-gamma)-deficient C57BL/6 (B6-GKO) mice and results in subacute fatal peritonitis, which bears a resemblance to feline infectious peritonitis. To examine the role of other host factors in MHV infection in mice, IFN-gamma-deficient mice with a BALB/c background (BALB-GKO) were infected intraperitoneally with MHV and compared with B6-GKO mice. In contrast to B6-GKO mice, BALB-GKO mice died within 1 week due to acute hepatic failure. The viral titer of the liver in BALB-GKO mice was significantly higher than that in B6-GKO mice. All hepatocytes in BALB-GKO mice were necrotic at 5 days post-infection, which was clearly distinct from large but limited lesion in the liver from infected B6-GKO mice. The serum alanine aminotransferase activity of infected BALB-GKO mice were higher than that of B6-GKO mice and was paralleled with the severity of the pathological changes and viral titers in infected mice. Administration of exogenous IFN-gamma to BALB-GKO partially inhibited the acute death. These results indicate that BALB-GKO and B6-GKO mice clearly show different diseases following MHV infection, although wild type counterparts of both mice apparently showed the same clinical course after MHV infection.
AuthorsShigeru Kyuwa, Shinwa Shibata, Yoh-ichi Tagawa, Yoichiroh Iwakura, Kenji Machii, Toru Urano
JournalVirus research (Virus Res) Vol. 83 Issue 1-2 Pg. 169-77 (Feb 26 2002) ISSN: 0168-1702 [Print] Netherlands
PMID11864749 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Interferon-gamma
  • Alanine Transaminase
Topics
  • Alanine Transaminase (blood)
  • Animals
  • Coronavirus Infections (blood, immunology, pathology, virology)
  • Hepatitis, Viral, Animal (blood, immunology, pathology, virology)
  • Injections, Intraperitoneal
  • Interferon-gamma (administration & dosage, genetics, immunology)
  • Liver Failure, Acute (blood, immunology, pathology, virology)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Murine hepatitis virus (growth & development, immunology)

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