Effects of 5-HT(3) antagonism on postprandial gastric volume and symptoms in humans.

Abstract

BACKGROUND:

Alosetron reduces symptoms of dyspepsia, but the physiological basis for the symptomatic benefit is unclear.

AIM:

To assess 5-HT3 antagonism on postprandial gastric volume and symptoms after ingestion of maximum tolerable volume of a liquid meal.

METHODS:

In 36 healthy volunteers, we assessed effects of placebo, 0.5 and 1 mg b.d. alosetron on fasting and postprandial gastric volumes (using single photon emission computed tomography) and symptoms based on 100 mm VAS, 30 min after maximum volume ingested.

RESULTS:

The 5-HT3 antagonist reduced postprandial symptoms (aggregate score: P < 0.05), nausea (P < 0.001), and tended to reduce bloating (P=0.08). Both 0.5 and 1 mg alosetron reduced nausea (P < 0.025); 1 mg alosetron reduced aggregate symptoms (P < 0.05) and bloating (P < 0.05). Effects on pain (P=0.19) and fullness (P=0.14) were not statistically significant. There were no significant effects of the 5-HT3 antagonist on volume of meal tolerated or on SPECT-measured fasting or postprandial gastric volumes.

CONCLUSION:

5-HT3 antagonism reduces aggregate symptoms, nausea and bloating after a liquid meal without increase in gastric volumes, suggesting a role for 5-HT3 in afferent functions in healthy humans during the postprandial period.

• Authors: B Kuo, M Camilleri, D Burton, B Viramontes, S McKinzie, G Thomforde, M K O'Connor, B H Brinkmann
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 16 Issue 2 Pg. 225-33 (Feb 2002) ISSN: 0269-2813 [Print] England
• PMID: 11860405 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carbolines
• Dietary Sucrose
• Serotonin Antagonists
• Ensure formulated food
• alosetron

Topics

• Adult
• Carbolines (administration & dosage, adverse effects, therapeutic use)
• Dietary Sucrose (administration & dosage, adverse effects)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Fasting
• Female
• Food, Formulated
• Humans
• Linear Models
• Male
• Nausea (prevention & control)
• Pain Measurement
• Postprandial Period (drug effects)
• Serotonin Antagonists (administration & dosage, adverse effects, therapeutic use)
• Stomach (drug effects)
• Tomography, Emission-Computed, Single-Photon