The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome.

Abstract

In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation (F1+2 and TATc) and fibrinolysis (t-PA, PAPc, and D-dimer). We found that TNF-alpha, IL-1beta and Il-1Ra, but not IL-6, concentrations were elevated in the circulation during the early stage of infection and at discharge from hospital. TNF-alpha was significantly associated with D-dimer, an activation marker of fibrinolysis (p < 0.003), but not with activation markers of coagulation. IL-1beta was significantly associated with t-PA (p < 0.03). IL-1Ra was significantly associated with F1+2, TATc (p < 0.04 and p < 0.02, respectively), whereas IL-6 was significantly associated with both, activation markers of coagulation (F1+2; p < 0.03) and fibrinolysis (PAPc; p = 0.002). Our data are in line with studies in bacterial sepsis. In severe dengue virus infection the same cytokines are involved in the onset and regulation of hemostasis.

• Authors: Catharina Suharti, Eric C M van Gorp, Tatty E Setiati, Wil M V Dolmans, Robert J Djokomoeljanto, C Erik Hack, Cate Hugo ten, Jos W M van der Meer
• Journal: Thrombosis and haemostasis (Thromb Haemost) Vol. 87 Issue 1 Pg. 42-6 (Jan 2002) ISSN: 0340-6245 [Print] Germany
• PMID: 11858187 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifibrinolytic Agents
• Biomarkers
• Cytokines
• Fibrin Fibrinogen Degradation Products
• IL1RN protein, human
• Interleukin 1 Receptor Antagonist Protein
• Interleukin-1
• Interleukin-6
• Peptide Fragments
• Sialoglycoproteins
• Tumor Necrosis Factor-alpha
• alpha-2-Antiplasmin
• antithrombin III-protease complex
• fibrin fragment D
• plasmin-plasmin inhibitor complex
• prothrombin fragment 1.2
• Antithrombin III
• Prothrombin
• Peptide Hydrolases
• Tissue Plasminogen Activator
• Fibrinolysin

Topics

• Adolescent
• Antifibrinolytic Agents (analysis)
• Antithrombin III (analysis)
• Biomarkers
• Child
• Child, Preschool
• Cytokines (blood, physiology)
• Disease Outbreaks
• Female
• Fibrin Fibrinogen Degradation Products (analysis)
• Fibrinolysin (analysis)
• Fibrinolysis
• Hemorrhagic Disorders (blood, etiology)
• Humans
• Indonesia (epidemiology)
• Interleukin 1 Receptor Antagonist Protein
• Interleukin-1 (blood, physiology)
• Interleukin-6 (blood, physiology)
• Male
• Peptide Fragments (analysis)
• Peptide Hydrolases (analysis)
• Prospective Studies
• Prothrombin (analysis)
• Severe Dengue (blood, epidemiology)
• Sialoglycoproteins (blood, physiology)
• Tissue Plasminogen Activator (analysis)
• Tumor Necrosis Factor-alpha (analysis, physiology)
• alpha-2-Antiplasmin (analysis)