Using a peptide inhibitor of the glycoprotein IIb/IIIa platelet receptor: initial experience in patients with acute peripheral arterial occlusions.

Abstract

OBJECTIVE:

The purpose of this study was to evaluate the efficacy of eptifibatide, an inhibitor of the glycoprotein (GP) IIb/IIIa platelet receptor, in the thrombolytic treatment of patients with acute peripheral arterial occlusive disease.

MATERIALS AND METHODS:

We retrospectively reviewed our experience with the use of a GP IIb/IIIa receptor inhibitor, eptifibatide, during thrombolysis in 17 patients with acute lower extremity arterial occlusions who also received intraarterial recombinant tissue plasminogen activator (rt-PA) and heparin. Four of the 17 patients received their loading dose of eptifibatide by direct intraarterial injection, whereas the remaining 13 received an IV loading dose. We compared their results with those of 11 other patients who received only rt-PA and heparin with respect to success and complication rates, duration of thrombolytic therapy, and total rt-PA dose.

RESULTS:

We found no significant difference in successful outcome (p = 1.00), major complications (p = 1.00), duration of therapy (p = 0.21), or total rt-PA dose (p = 0.67) between those who received eptifibatide and those who did not during thrombolytic therapy. However, those patients who received an intraarterial loading dose of eptifibatide required substantially less rt-PA (9.0 +/- 4.4 mg vs 38.9 +/- 30.7 mg) to achieve successful thrombolysis.

CONCLUSION:

The adjunctive use of a GP IIb/IIIa platelet receptor inhibitor during thrombolysis for arterial occlusions may decrease the total dose of rt-PA required for thrombolysis without compromising success or complication rates. A prospective randomized study is needed to confirm that inhibitors of the GP IIb/IIIa platelet receptor can facilitate thrombolytic therapy in patients with acute lower extremity arterial occlusions.

• Authors: Hyo-Chun Yoon, Franklin J Miller Jr
• Journal: AJR. American journal of roentgenology (AJR Am J Roentgenol) Vol. 178 Issue 3 Pg. 617-22 (Mar 2002) ISSN: 0361-803X [Print] United States
• PMID: 11856686 (Publication Type: Journal Article)

Chemical References

• Fibrinolytic Agents
• Peptides
• Platelet Aggregation Inhibitors
• Platelet Glycoprotein GPIIb-IIIa Complex
• Heparin
• Plasminogen Activators
• Tissue Plasminogen Activator
• Eptifibatide

Topics

• Acute Disease
• Adult
• Aged
• Aged, 80 and over
• Arterial Occlusive Diseases (drug therapy)
• Eptifibatide
• Female
• Fibrinolytic Agents (therapeutic use)
• Graft Occlusion, Vascular
• Heparin (adverse effects, therapeutic use)
• Humans
• Leg (blood supply)
• Male
• Middle Aged
• Peptides (adverse effects, therapeutic use)
• Plasminogen Activators (therapeutic use)
• Platelet Aggregation Inhibitors (therapeutic use)
• Platelet Glycoprotein GPIIb-IIIa Complex (antagonists & inhibitors)
• Retrospective Studies
• Thrombolytic Therapy (adverse effects)
• Thrombosis (drug therapy)
• Tissue Plasminogen Activator (adverse effects, therapeutic use)