Abstract | OBJECTIVES: To investigate the effect of growth hormone on proliferative activity of the residual small intestinal mucosa after massive small intestinal resection and to evaluate the clinical efficacy of bowel rehabilitative therapy for short bowel syndrome. METHODS: Small intestinal mucosa proliferative activity were compared in rats from control group ( sham operation), short bowel group (80% small bowel resection) and growth hormone treatment group (80% small bowel resection + growth hormone 1 U x kg(-1) x d(-1) for 28 days) with the aid of histology image analysis, flow cytometric assay, immunohistochemistry analysis and RT-PCR assay. The nutritional status, D-xylose absorption and stool nitrogen output were observed in 9 consecutive parenteral nutrition dependent patients with short bowel syndrome after intestinal rehabilitative therapy ( growth hormone 8 - 12 U x kg(-1) x d(-1) im + glutamine 0.6 g x kg(-1) x d(-1) iv + special diet) for 21 continuous days. RESULTS: CONCLUSION:
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Authors | N Li, W Zhu, F Guo, J Ren, Y Li, X Wang, J Li |
Journal | Zhonghua wai ke za zhi [Chinese journal of surgery]
(Zhonghua Wai Ke Za Zhi)
Vol. 38
Issue 8
Pg. 565-9
(Aug 2000)
ISSN: 0529-5815 [Print] China |
PMID | 11832109
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Animals
- Cell Division
(drug effects)
- Child
- Combined Modality Therapy
- Follow-Up Studies
- Glutamine
(therapeutic use)
- Growth Hormone
(therapeutic use)
- Humans
- Injections, Intramuscular
- Intestinal Mucosa
(cytology, drug effects)
- Intestine, Small
- Middle Aged
- Parenteral Nutrition, Total
- Rats
- Rats, Sprague-Dawley
- Short Bowel Syndrome
(drug therapy, rehabilitation)
- Treatment Outcome
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