[Results of the ECHODIAH clinical trial on hip arthrosis].

Abstract

STUDY OBJECTIVE:

The principal objective of ECHODIAH study conducted in patients with hip osteoarthritis was to evaluate the chondroprotective effect of potential of diacerein compared with placebo. The study was conducted over a 3-year period using progression of joint space narrowing as the assessment criterion.

RESULTS:

For aggravation, expressed as joint space narrowing of at least 0.5 mm, there were significantly fewer patients in the diacerein group than in the placebo group; aggravation came significantly later in the diacerhein group. In the population of patients who completed at least 3 months treatment, the sparing effect on joint space narrowing was 32% in the diacerhein group compared with the placebo group. In addition, the mean progression of joint space narrowing was significantly less in patients treated with diacerein; the mean progression decreased from 0.18 mm/year at the end of the first year to 0.13 mm/year at the end of the third year.

• Authors: E Vignon
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 31 Issue 1 Pt 2 Pg. 7-9 (Jan 12 2002) ISSN: 0755-4982 [Print] France
• Vernacular Title: Résultats de l'essai thérapeutique ECHODIAH dans l'arthrose de hanche.
• PMID: 11826591 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Anthraquinones
• Anti-Inflammatory Agents, Non-Steroidal
• diacerein

Topics

• Anthraquinones (therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Double-Blind Method
• Female
• Humans
• Male
• Osteoarthritis, Hip (drug therapy)