[Protective effects of a Ginkgo biloba extract (EGb 761) on ischemia-reperfusion injury].

Abstract

EGb 761 is a standardized extract of dried leaves of Ginkgo biloba. EGb 761 is a neuroprotective and anti-ischaemic drug. Its broad spectrum of pharmacological activities allows it to be adequate to the numerous pathological requirements--haemodynamic, haemorrheological, metabolic--which occur in cerebral, retinal, cochleovestibular, cardiac or peripheral ischaemia. Moreover, EGb 761 has direct effects in retinal and myocardial ischaemia and reperfusion injuries. EGb 761 improves retinal microcirculation, reduces oedema of the retinal inner layer and protects chemoreceptors against free-radical injuries. On myocardial ischaemia-reperfusion models, EGb 761 improves myocardial functional recovery, and reduces the number of ventricular extrasytoles and the duration of ventricular tachycardia induced by reperfusion. EGb 761 protects the retina and the heart against ischaemia-reperfusion damage via its free radical-scavenging and anti-lipoperoxidative properties and its regulation of mitochondrial respiratory function.

• Authors: F Clostre
• Journal: Therapie (Therapie) 2001 Sep-Oct Vol. 56 Issue 5 Pg. 595-600 ISSN: 0040-5957 [Print] France
• Vernacular Title: Effets protecteurs de l'extrait de Ginkgo biloba (EGb 761) sur les lésions tissulaires de l'ischémie-reperfusion.
• PMID: 11806299 (Publication Type: Journal Article, Review)

Chemical References

• Plant Extracts
• Ginkgo biloba extract

Topics

• Animals
• Ginkgo biloba
• Humans
• Oxygen Consumption (drug effects)
• Phytotherapy
• Plant Extracts (therapeutic use)
• Reperfusion Injury (drug therapy)