Cardiovascular histamine receptors in the domestic chicken.

Abstract

The effects of mepyramine (H1-antagonist) and burimamide (H2-antagonist) were studied on histamine, 2-methylhistamine (a selective H1-agonist), 4-methylhistamine (a selective H2-agonist) and acetylcholine-induced changes in systemic arterial and central venous pressure and respiration in anaesthetized chickens. The result of this study suggested a predominance of H1 and some H2 histamine receptors in the cardiovascular system of domestic fowl where both are mediating systemic hypotension. There also appears to be predominance of H1 receptors mediating venous hypertension and respiratory apnoea to large doses of histamine and 2-methylhistamine. In addition, a possible involvement of H2-receptors in the cardiovascular system of chicken is suggested by the finding that burimamide always blocked mepyramine potentiated secondary pressor response to histamine and its analogues.

• Authors: N Chand, P Eyre
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 216 Issue 2 Pg. 197-207 (Aug 1975) ISSN: 0003-9780 [Print] Belgium
• PMID: 1180613 (Publication Type: Journal Article)

Chemical References

• Receptors, Drug
• Histamine
• Pyrilamine
• Acetylcholine
• Burimamide

Topics

• Acetylcholine (pharmacology)
• Animals
• Blood Pressure (drug effects)
• Burimamide (pharmacology)
• Central Venous Pressure (drug effects)
• Chickens
• Depression, Chemical
• Female
• Hemodynamics (drug effects)
• Histamine (analogs & derivatives, pharmacology)
• Pyrilamine (pharmacology)
• Receptors, Drug (drug effects)