Crystalline inclusions in granulocytic sarcoma.

Abstract

Two cases of granulocytic sarcoma were found to contain numerous crystalline inclusions identified on hematoxylin-eosin-stained sections as clusters of pointed needlelike crystals present in foci of necrosis or within macrophages. The crystals were negative for chloroacetate esterase and myeloperoxidase. Electron microscopy demonstrated homogeneously dense, bipyramidal structures, indistinguishable from Charcot-Leyden crystals. Granulocytic sarcomas may contain crystalline inclusions similar to Charcot-Leyden crystals; these structures should be distinguished from crystalline immunoglobulin inclusions occurring in cases of plasma cell myeloma and lymphoplasmacytic lymphoma, which may have a similar appearance.

• Authors: James A Strauchen, Ronald E Gordon
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 126 Issue 1 Pg. 85-6 (Jan 2002) ISSN: 0003-9985 [Print] United States
• PMID: 11800655 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glycoproteins
• Lysophospholipase
• lysolecithin acylhydrolase

Topics

• Bone Neoplasms (metabolism, pathology)
• Crystallization
• Fatal Outcome
• Female
• Glycoproteins
• Humans
• Lysophospholipase
• Mandibular Neoplasms (metabolism, pathology)
• Microscopy, Electron
• Middle Aged
• Sarcoma, Myeloid (metabolism, pathology)