[The effects of high dose atropine on function of isolated diaphragmatic preparation of rats with omethoate poisoning].

Abstract

OBJECTIVE:

The study was designed to examine the influence of high dose atropine on respiratory muscle of rat isolated phrenic diaphragm.

METHODS:

Rats were divided into 2 groups: (1) a toxic group administered with 2LD(50) omethoate, SC. (2) a contrast group with 0.9% NS, SC. The function of isolated rat phrenic diaphragm was observed by MS-302 analysis instrument physiologically and pharmacologically.

RESULTS:

In both groups the function of isolated rat phrenic diaphragm was significantly reduced with atropine dose increasing gradually to 0.6 mg (P < 0.01). When the atropine dose amounted to 0.8 mg. The function of isolated rat phrenic diaphragm almost disappeared in the picture. When the atropine in the diaphragm was weed out, the function of isolated rat phrenic diaphragm recovered completely in 50 minutes.

CONCLUSION:

It is suggested that the cause of respiratory muscle paralysis may be related to high dose of atropine.

• Authors: Z Qiu, D Zhao, Y Shi, Y Liu
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 40 Issue 3 Pg. 187-9 (Mar 2001) ISSN: 0578-1426 [Print] China
• PMID: 11798578 (Publication Type: English Abstract, Journal Article)

Chemical References

• dimethoxon
• Atropine
• Dimethoate

Topics

• Animals
• Atropine (administration & dosage, toxicity)
• Dimethoate (analogs & derivatives, toxicity)
• Female
• Male
• Muscle Contraction
• Phrenic Nerve (physiology)
• Rats
• Respiratory Muscles (drug effects)
• Respiratory Paralysis (complications)