Abstract | OBJECTIVE: METHODS: RESULTS:
IGF-I messenger RNA and protein levels in hypertrophic myocardium were 2.6 and 2.9 times greater, respectively, than in nonhypertrophic myocardium of the same patients (both P <.01). TGF-beta 1 messenger RNA and protein levels in the hypertrophic myocardium were 2.5 and 2.8 times greater, respectively, than the levels in the nonhypertrophied myocardium (both P <.01). There was a significant correlation between the IGF-I protein ratio (hypertrophic/nonhypertrophic myocardium) and the inducible left ventricular outflow tract gradients measured at cardiac catheterization (r = 0.77, P =.025). CONCLUSIONS:
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Authors | Guangming Li, Michael A Borger, William G Williams, Richard D Weisel, Donald A G Mickle, E Douglas Wigle, Ren-Ke Li |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 123
Issue 1
Pg. 89-95
(Jan 2002)
ISSN: 0022-5223 [Print] United States |
PMID | 11782760
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Messenger
- Receptors, Transforming Growth Factor beta
- TGFB1 protein, human
- Transforming Growth Factor beta
- Transforming Growth Factor beta1
- Insulin-Like Growth Factor I
- Receptor, IGF Type 1
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Topics |
- Cardiomyopathy, Hypertrophic
(metabolism, surgery)
- Female
- Humans
- Insulin-Like Growth Factor I
(genetics, metabolism)
- Male
- Middle Aged
- Myocardium
(metabolism)
- RNA, Messenger
(metabolism)
- Receptor, IGF Type 1
(metabolism)
- Receptors, Transforming Growth Factor beta
(metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Transforming Growth Factor beta
(genetics, metabolism)
- Transforming Growth Factor beta1
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