[Mechanisms of bone repairment in periapical diseases: studies on adjusting bone metabolism with calcium hydroxide in vitro].

Abstract

OBJECTIVE:

To provide experiment evidence for clinical practice and for further exploration on mechanism and medicinal control of periapical diseases.

METHODS:

The culture model of neonatal mouse calvariae which has the similar biological activity to alveolar bone was established in vitro to observe the influence of calcium hydroxide on osteo-activity.

RESULTS:

The results showed that calcium hydroxide with proper concentration at organ culture level could enhance osteoblast ALP secreting activity, and increased the tendency of bone formation. At the same time, the concentration of inorganic PO4(3-) in culture medium also had significant changes.

CONCLUSIONS:

The mechanism of calcium hydroxide promoting repairment of bone tissues is not only by providing rich Ca2+ and alkaline environment mineral deposition, but also by stimulating calcification enzyme activity of osteoblast. Meanwhile, increased PO4(3-) concentration might improve the mineralization environment, which causes mineralization easily.

• Authors: Y Liang, J Wang, S Yu
• Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology (Zhonghua Kou Qiang Yi Xue Za Zhi) Vol. 35 Issue 2 Pg. 112-4 (Mar 2000) ISSN: 1002-0098 [Print] China
• PMID: 11780478 (Publication Type: Journal Article)

Chemical References

• Phosphates
• Alkaline Phosphatase
• Calcium Hydroxide

Topics

• Alkaline Phosphatase (drug effects, metabolism)
• Animals
• Animals, Newborn
• Bone and Bones (drug effects, physiopathology)
• Calcium Hydroxide (pharmacology)
• Dose-Response Relationship, Drug
• Mice
• Organ Culture Techniques
• Osteoblasts (drug effects, enzymology)
• Periapical Diseases (drug therapy, physiopathology)
• Phosphates (pharmacology)
• Skull (drug effects, growth & development)
• Time Factors