Persistent efficacy of doramectin topical solution against induced infestations of Bovicola bovis and Solenopotes capillatus.

Abstract

A study was conducted in two locations, Wyoming and Wisconsin, USA, to evaluate the persistent efficacy of doramectin topical solution at a dose rate of 500 microg/kg body weight against artificially induced infestations of Bovicola bovis and Solenopotes capillatus on cattle. At each location, lice-free beef calves were individually housed and randomly allocated to treatment. Both B. bovis and S. capillatus were transferred from untreated donor animals to doramectin-treated cattle at the end of 35, 63, 91 or 126 day post-treatment periods. Cattle treated with a saline pour-on served as the control. Based on the geometric means of lice counts 2 weeks following transfer, the persistent efficacy of a single treatment with doramectin topical solution against induced infestations of B. bovis was 100.0, 100.0, 99.5, and 100.0% at post-treatment days of 35, 63, 91, and 126, respectively. Persistent efficacy against induced infestations of S. capillatus, for the same intervals, were 100.0, 94.9, 86.3, and 74.9%.

• Authors: J E Lloyd, R Kumar, M A Grubbs, J W Waggoner, E E Norelius, L L Smith, A C Brake, T L Skogerboe, V K Shostrom
• Journal: Veterinary parasitology (Vet Parasitol) Vol. 102 Issue 3 Pg. 235-41 (Dec 13 2001) ISSN: 0304-4017 [Print] Netherlands
• PMID: 11777603 (Publication Type: Journal Article)

Chemical References

• Anthelmintics
• Solutions
• Ivermectin
• doramectin

Topics

• Administration, Topical
• Animals
• Anoplura (drug effects)
• Anthelmintics (administration & dosage, pharmacology)
• Cattle
• Cattle Diseases (drug therapy, parasitology, prevention & control)
• Female
• Ivermectin (administration & dosage, analogs & derivatives, pharmacology)
• Lice Infestations (drug therapy, prevention & control, veterinary)
• Male
• Parasitic Sensitivity Tests (veterinary)
• Phthiraptera (drug effects, growth & development)
• Random Allocation
• Solutions
• Time Factors
• Treatment Outcome