The effect of estradiol vaginal tablet and conjugated estrogen cream on urogenital symptoms in postmenopausal women: a comparative study.

Abstract

OBJECTIVES:

To compare the effects of estradiol vaginal tablet with conjugated estrogen cream on urogenital symptoms, vaginal health index, vaginal cytology, endometrial thickness, and plasma estradiol level in postmenopausal women.

METHODS:

Fifty-three women with urogenital symptoms were randomized to local vaginal treatment of 25 microg estradiol tablet or 1 g of conjugated estrogen cream for 12 weeks. They were assessed for urogenital symptoms, vaginal health index, vaginal cytology, endometrial thickness and estradiol level.

RESULTS:

Forty-eight women completed the treatment. Both groups showed improvement of urogenital symptoms, vaginal health index, and vaginal cytology after the first 4 weeks of treatment. Conjugated estrogen cream showed superior efficacy in alleviating vaginal dryness and dyspareunia. Two cases of endometrial proliferation were noted.

CONCLUSIONS:

Estradiol vaginal tablet and conjugated estrogen cream were effective in treating urogenital symptoms, the restoration of normal vaginal epithelium and reduction of vaginal pH in postmenopausal women. However, 2 cases of endometrial proliferation were noted.

• Authors: J Manonai, U Theppisai, S Suthutvoravut, U Udomsubpayakul, A Chittacharoen
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 27 Issue 5 Pg. 255-60 (Oct 2001) ISSN: 1341-8076 [Print] Australia
• PMID: 11776507 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Estrogens, Conjugated (USP)
• Tablets
• Vaginal Creams, Foams, and Jellies
• Estradiol

Topics

• Administration, Intravaginal
• Endometrium (drug effects)
• Estradiol (therapeutic use)
• Estrogens, Conjugated (USP) (therapeutic use)
• Female
• Humans
• Middle Aged
• Postmenopause
• Tablets
• Urethritis (drug therapy)
• Vagina (cytology, drug effects)
• Vaginal Creams, Foams, and Jellies
• Vaginitis (drug therapy)