[The effect of Nifedipine on postpartum blood loss in patients with pregnancy induced hypertension].

Abstract

OBJECTIVE:

To determine the efficacy of Nifedipine on postpartum blood Loss in patients with Pregnancy Induced Hypertension (PIH).

METHODS:

64 cases of PIH were randomly divided into study group (n = 32) and control group (n = 32). Before labor Nifedipine 10 mg-20 mg was given three time daily for all cases. In study group Nifedipine was taken orally every 6 hours during the labor course until the end of second stage. In control group Nifedipine was not given in the labor stages. The postpartum blood loss was collected and measured carefully within 2 hours after delivery.

RESULTS:

The amount of pastpartum hemorrhage was (359.1 +/- 136.6) ml in study group which was significantly higher than that of control group (268.5 +/- 110.7) ml P < 0.01. The postpartum hemorrhage rate in study and control group was 43.75% and 18.75% respectively. The difference was statistically significant (P < 0.05).

CONCLUSION:

During labor using Nifedipine for PIH cases can increase the amount of postpartum blood loss and rate of postpartum hemorrnage.

• Authors: X Yang, Y Liu
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 35 Issue 3 Pg. 151-2 (Mar 2000) ISSN: 0529-567X [Print] China
• PMID: 11775892 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Calcium Channel Blockers
• Nifedipine

Topics

• Calcium Channel Blockers (adverse effects)
• Female
• Humans
• Hypertension (drug therapy)
• Nifedipine (adverse effects)
• Postpartum Hemorrhage (chemically induced)
• Pregnancy
• Pregnancy Complications, Cardiovascular (drug therapy)