Abstract | BACKGROUND: METHODS: RESULTS: From 1990 to 1999 (10 years) 139 patients underwent restorative proctocolectomy and ileo-anal pouch anastomosis (135 J pouches and 4 W pouches). Their median age was 35 years (range 13-74). There were 68 females and 71 males. The indication for operation was failed medical treatment in 104 patients and toxic megacolon in 35. Forty-seven patients (34%) developed pouchitis (21 females and 26 males). Symptoms were diarrhoea (35), diarrhoea, mucus and pus (5) and diarrhoea and blood (7). Symptoms of pouchitis started at an average of 33.51 + 29.2 months (range 2-102, median 18). All patients were treated with metronidazole for a minimum of one month. Thirty-six patients (77%) resolved on metronidazole alone. Nine patients (19%) went on to develop chronicity and were managed by long-term metronidazole (and/or ciprofloxacin). A further 2 patients (4%) had treatment resistant pouchitis and required pouch excision. CONCLUSION:
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Authors | T E Madiba, D C Bartolo |
Journal | Journal of the Royal College of Surgeons of Edinburgh
(J R Coll Surg Edinb)
Vol. 46
Issue 6
Pg. 334-7
(Dec 2001)
ISSN: 0035-8835 [Print] Scotland |
PMID | 11768572
(Publication Type: Journal Article)
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Chemical References |
- Anti-Infective Agents
- Metronidazole
|
Topics |
- Adolescent
- Adult
- Aged
- Anti-Infective Agents
(therapeutic use)
- Child
- Colitis, Ulcerative
(surgery)
- Female
- Humans
- Incidence
- Male
- Metronidazole
(therapeutic use)
- Middle Aged
- Pouchitis
(drug therapy, etiology)
- Proctocolectomy, Restorative
(adverse effects)
- Scotland
- Treatment Outcome
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