Treatment of pigs experimentally infected with Mycoplasma hyopneumoniae, Pasteurella multocida, and Actinobacillus pleuropneumoniae with various antibiotics.

Abstract	The authors have performed a comparative study of the efficacy of various in-feed medications for the treatment of 5- to 6-week-old specific pathogen-free (SPF) piglets experimentally infected on day 1 with Mycoplasma hyopneumoniae, on day 8 with Pasteurella multocida (serotype A), and on day 15 with Actinobacillus pleuropneumoniae (serotype 2). The treatment started on day 9 and continued for 12 consecutive days, then the piglets were euthanized for examination of macroscopic, histologic, and pathologic lesions and for the presence of mycoplasmas and bacteria in the lungs. Based on the results of clinical observations (respiratory signs, rectal temperature, body weight gain, and feed conversion efficiency), macroscopic and histologic lesions of the lungs, and microbiologic findings, the best results were obtained by treatment of pigs with Econor + chlortetracycline, followed by Tetramutin, Pulmotil, Cyfac, and lincomycin + chlortetracycline.
Authors	L Stipkovits, D Miller, R Glavits, L Fodor, D Burch
Journal	Canadian journal of veterinary research = Revue canadienne de recherche veterinaire (Can J Vet Res) Vol. 65 Issue 4 Pg. 213-22 (Oct 2001) ISSN: 0830-9000 [Print] Canada
PMID	11768127 (Publication Type: Journal Article)
Chemical References	Anti-Bacterial Agents Diterpenes valnemulin Chlortetracycline
Topics	Actinobacillus Infections (drug therapy, pathology, veterinary) Actinobacillus pleuropneumoniae (drug effects, growth & development) Animal Feed Animals Anti-Bacterial Agents (pharmacology, therapeutic use) Chlortetracycline (pharmacology, therapeutic use) Diterpenes (pharmacology, therapeutic use) Drug Therapy, Combination Mycoplasma (drug effects, growth & development) Mycoplasma Infections (drug therapy, pathology, veterinary) Pasteurella Infections (drug therapy, pathology, veterinary) Pasteurella multocida (drug effects, growth & development) Specific Pathogen-Free Organisms Swine Swine Diseases (drug therapy, microbiology, pathology) Treatment Outcome Weight Gain

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