Abstract |
To evaluate clinical significance of measurement of urinary leukotriene E4 ( LTE4) in asthmatic patients without attack, we measured urinary LTE4 in 68 asthmatic patients without attack and investigated its correlation with severity of asthma, % FEV1, bronchial hyperresponsiveness and peripheral eosinophil counts. Values of urinary LTE4 were significantly higher in the asthmatic patients (113.6 +/- 9.7 pg/mg.cr) than in healthy control subjects (67.8 +/- 4.7, n = 31), and the level of urinary LTE4 was in proportion to the severity of disease. Urinary LTE4 showed significant negative correlation with % FEV1 in atopic patients (Rs = -0.43, p = 0.025, n = 28), which was not recognized in non-atopic patients. Urinary LTE4 showed no significant correlation with bronchial hyperresponsiveness and peripheral eosinophil counts. Our findings suggested that basal LTE4 in urine reflected chronic airway inflammation of asthma.
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Authors | Y Kawagishi, R Oosaki, H Mita, M Maruyama, N Arai, H Taniguchi, T Kashii, N Yamashita, M Taniguchi, K Akiyama, M Kobayashi |
Journal | Arerugi = [Allergy]
(Arerugi)
Vol. 50
Issue 11
Pg. 1096-101
(Nov 2001)
ISSN: 0021-4884 [Print] Japan |
PMID | 11761885
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adult
- Asthma
(diagnosis, physiopathology, urine)
- Bronchial Hyperreactivity
(urine)
- Female
- Humans
- Leukotriene D4
(urine)
- Male
- Middle Aged
- Severity of Illness Index
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