[Radiotherapy of early stage Dupuytren disease. Long-term results after a median follow-up period of 10 years].

Abstract

PURPOSE:

In early stage Dupuytren's contracture radiotherapy was applied to prevent disease progression. Long-term results and late toxicity of this treatment were evaluated in a retrospective analysis.

PATIENTS AND METHODS:

Between 1982 and 1994, 99 patients (176 hands) received orthovoltage radiotherapy, which consisted of two courses with 5 x 3 Gy (total dose: 30 Gy, daily fractionated; 120 kV, 4 mm Al), separated by a 6 to 8-week pause. The Dupuytren's contracture was staged according to the classification of Tubiana et al. The long-term outcome was analyzed at last follow-up between July and November 1999. The median follow-up was 10 years (range 7-18 years). Late toxicity was assessed using the LENT-SOMA criteria.

RESULTS:

In Stage N 84% and Stage N/I 67% of cases remained stable. 65% of the cases in Stage I and 83% in Stage II showed progressive nodules and cords. In case of progression we saw no complications after a second radiotherapy or salvage operation.

CONCLUSION:

Radiotherapy effectively prevents disease progression for early stage Dupuytren's contracture (Stage N, N/I). Moreover, in case of disease progression despite radiotherapy salvage surgery is still feasible.

• Authors: B Adamietz, L Keilholz, J Grünert, R Sauer
• Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (Strahlenther Onkol) Vol. 177 Issue 11 Pg. 604-10 (Nov 2001) ISSN: 0179-7158 [Print] Germany
• Vernacular Title: Die Radiotherapie des Morbus Dupuytren im Frühstadium. Langzeitresultate nach einer medianen Nachbeobachtungszeit von 10 Jahren.
• PMID: 11757183 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Disease Progression
• Dose Fractionation, Radiation
• Dupuytren Contracture (diagnosis, radiotherapy)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Retrospective Studies