Abstract |
We describe 5 cases of "compound blue nevus" (CBN) ("superficial blue nevus with prominent intraepidermal dendritic melanocytes," "Kamino nevus"). Dermoscopically in 2 of 4 cases the bluish pigmentation characteristic of blue nevi was centrally replaced by a black lamella, with black dots and brown globules also observed in one case, thus revealing a structural asymmetry suggestive of melanoma. Histopathologically, pigmented parakeratosis was the underlying histopathologic finding of black lamella and dots/globules. Immunohistochemistry highlighted the unique histopathologic feature of CBN, namely, single dendritic melanocytes at the dermoepidermal junction with striking intraepidermal prolongations. Our findings confirm that CBN is a distinctive variant of blue nevus that may mimic cutaneous melanoma both clinically and dermoscopically.
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Authors | Gerardo Ferrara, Giuseppe Argenziano, Borut Zgavec, Igor Bartenjev, Stefania Staibano, Gaetano De Rosa, H Peter Soyer |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 46
Issue 1
Pg. 85-9
(Jan 2002)
ISSN: 0190-9622 [Print] United States |
PMID | 11756951
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adolescent
- Adult
- Arm
- Child
- Dendritic Cells
(pathology)
- Diagnosis, Differential
- Female
- Humans
- Immunohistochemistry
- Male
- Melanocytes
(pathology)
- Melanoma
(pathology)
- Microscopy
- Neck
- Nevus, Blue
(pathology)
- Skin Neoplasms
(pathology)
- Thorax
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