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Clinical and oculographic response to Tenuate Dospan (diethylpropionate) in a patient with congenital nystagmus.

AbstractPURPOSE:
We report a female adult with congenital nystagmus who responded with improved visual function and oculographic parameters after taking the anorexic diet drug Tenuate Dospan (diethylproprionate; Watson Laboratories, Inc., Corona, California).
METHODS:
Observational case report. Clinical ophthalmic examination and ocular motility recordings were performed before and after administration of the drug Tenuate Dospan.
RESULTS:
The binocular visual acuity of the patient improved from 20/70 to 20/50, her exotropic deviation decreased from 12 to 4 prism diopters, her stereopsis increased from none to 200 seconds/arc, and her ocular motility recordings showed increased foveation periods and a broadened null zone.
CONCLUSION:
For unexplained reasons, the anorexic stimulant Tenuate Dospan "paradoxically" improved the nystagmus and binocular function in this patient with congenital nystagmus. This observation may be the basis for investigation of a new pharmacological treatment approach to patients with congenital nystagmus or strabismus.
AuthorsRichard W Hertle, Mitra Maybodi, Susan D Mellow, Dongsheng Yang
JournalAmerican journal of ophthalmology (Am J Ophthalmol) Vol. 133 Issue 1 Pg. 159-60 (Jan 2002) ISSN: 0002-9394 [Print] United States
PMID11755862 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Appetite Depressants
  • Diethylpropion
Topics
  • Appetite Depressants (therapeutic use)
  • Diethylpropion (therapeutic use)
  • Electrooculography (drug effects)
  • Eye Movements (drug effects, physiology)
  • Female
  • Humans
  • Middle Aged
  • Nystagmus, Congenital (drug therapy, physiopathology)
  • Vision, Binocular (drug effects)
  • Visual Acuity (drug effects)

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