Clinical and oculographic response to Tenuate Dospan (diethylpropionate) in a patient with congenital nystagmus.

We report a female adult with congenital nystagmus who responded with improved visual function and oculographic parameters after taking the anorexic diet drug Tenuate Dospan (diethylproprionate; Watson Laboratories, Inc., Corona, California).
Observational case report. Clinical ophthalmic examination and ocular motility recordings were performed before and after administration of the drug Tenuate Dospan.
The binocular visual acuity of the patient improved from 20/70 to 20/50, her exotropic deviation decreased from 12 to 4 prism diopters, her stereopsis increased from none to 200 seconds/arc, and her ocular motility recordings showed increased foveation periods and a broadened null zone.
For unexplained reasons, the anorexic stimulant Tenuate Dospan "paradoxically" improved the nystagmus and binocular function in this patient with congenital nystagmus. This observation may be the basis for investigation of a new pharmacological treatment approach to patients with congenital nystagmus or strabismus.
AuthorsRichard W Hertle, Mitra Maybodi, Susan D Mellow, Dongsheng Yang
JournalAmerican journal of ophthalmology (Am J Ophthalmol) Vol. 133 Issue 1 Pg. 159-60 (Jan 2002) ISSN: 0002-9394 [Print] United States
PMID11755862 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Appetite Depressants
  • Diethylpropion
  • Appetite Depressants (therapeutic use)
  • Diethylpropion (therapeutic use)
  • Electrooculography (drug effects)
  • Eye Movements (drug effects, physiology)
  • Female
  • Humans
  • Middle Aged
  • Nystagmus, Congenital (drug therapy, physiopathology)
  • Vision, Binocular (drug effects)
  • Visual Acuity (drug effects)

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