Abstract |
We describe a 52-year-old man with paroxysmal nocturnal hemoglobinuria (PNH) and a moderate transfusion requirement. Prior to and during sequential therapy with androgen ( metenolone), glucocorticoid, and danazol, we evaluated CD59-negative expression (PNH clone) in red blood cells, neutrophils, lymphocyte subsets, and bone marrow (BM) CD34(+) cells. Although androgen and glucocorticoid were not effective for recovery of blood cell counts, the hemoglobin and platelet levels increased immediately after the therapy with danazol and the patient became transfusion independent. However, neither the serum level of LDH nor the percentage of PNH clone in each cell lineage, including BM CD34(+) cells, decreased. The number of nucleated cells in BM increased drastically after the start of danazol. These findings suggest that the efficacy of danazol was not only due to the impediment of hemolysis but also due to stimulation of PNH clone proliferation in BM.
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Authors | Y Katayama, Y Hiramatsu, K Kohriyama |
Journal | American journal of hematology
(Am J Hematol)
Vol. 68
Issue 4
Pg. 280-3
(Dec 2001)
ISSN: 0361-8609 [Print] United States |
PMID | 11754418
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright 2001 Wiley-Liss, Inc. |
Chemical References |
- CD59 Antigens
- Estrogen Antagonists
- Danazol
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Topics |
- Blood Cells
(drug effects)
- Bone Marrow Cells
(drug effects)
- CD59 Antigens
(blood)
- Cell Count
- Clone Cells
(drug effects)
- Danazol
(administration & dosage, pharmacology)
- Estrogen Antagonists
(administration & dosage, pharmacology)
- Hemoglobinuria, Paroxysmal
(blood, drug therapy, pathology)
- Humans
- Male
- Middle Aged
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