Abstract |
B cell hybridomas expressing class I and II MHC molecules and producing antibodies directed against hemagglutinin protein of Rinderpest virus and human Mucin-1 have been used as surrogate B cells to study T cell responses against the antigens. The observed CTL and lymphoproliferative response indicates that anti-idiotypic B cells termed Jerne cells stimulate both T helper and T cytotoxic cells by virtue of their ability to present recycled or regurgitated peptido-mimics of antigen to T helper cells through class II MHC and de novo synthesized peptido-mimics of antigens to CTLs. Thus, T cell memory response can be perpetuated by anti-idiotypic Jerne B cells and these findings lend support to the earlier proposed relay hypothesis for perpetuation of immunological memory (IM).
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Authors | Shibani Mitra-Kaushik, M S Shaila, Anjali Karande, Rabindranath Nayak |
Journal | Immunology letters
(Immunol Lett)
Vol. 80
Issue 2
Pg. 81-7
(Feb 01 2002)
ISSN: 0165-2478 [Print] Netherlands |
PMID | 11750038
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies
- Antigens, Neoplasm
- Epitopes
- Hemagglutinins, Viral
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Topics |
- Animals
- Antibodies
(immunology)
- Antigens, Neoplasm
(immunology)
- B-Lymphocytes
(immunology)
- Cell Transplantation
- Epitopes
(immunology)
- Hemagglutinins, Viral
(immunology)
- Humans
- Hybridomas
(immunology, transplantation)
- Mice
- T-Lymphocytes, Cytotoxic
(immunology)
- T-Lymphocytes, Helper-Inducer
(immunology)
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