Abstract | BACKGROUND: AIM: METHODS: Randomized controlled trials comparing thymosin for over 24 weeks vs. placebo (or usual care) in the treatment of chronic hepatitis B virus infection were identified through MEDLINE, EMBASE and the Cochrane Register of Clinical Trials. Biochemical (normalization of transaminases) and virological (loss of hepatitis B virus DNA and hepatitis B e antigen) responses were analysed using the intention-to-treat method. The odds ratio was used to measure the magnitude of the efficacy. RESULTS: Five trials (353 patients) were identified. The odds ratio (95% confidence interval) of the virological response of thymosin over placebo at the end of treatment, 6 months post-treatment and 12 months post-treatment were 0.56 (0.2-1.52), 1.67 (0.83-3.37) and 2.67 (1.25-5.68), respectively. There was an increasing trend of the virological response with time since the cessation of thymosin treatment (P=0.02). There was no difference in the biochemical response between the thymosin and placebo groups at the end of treatment, 6 months post-treatment and 12 months post-treatment. CONCLUSIONS:
|
Authors | H L Chan, J L Tang, W Tam, J J Sung |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 15
Issue 12
Pg. 1899-905
(Dec 2001)
ISSN: 0269-2813 [Print] England |
PMID | 11736720
(Publication Type: Journal Article, Meta-Analysis)
|
Chemical References |
- Antiviral Agents
- DNA, Viral
- Hepatitis B e Antigens
- Thymosin
- Transaminases
|
Topics |
- Antiviral Agents
(therapeutic use)
- DNA, Viral
(analysis)
- Hepatitis B e Antigens
(analysis)
- Hepatitis B virus
(drug effects, genetics, pathogenicity)
- Hepatitis B, Chronic
(drug therapy, immunology, virology)
- Humans
- MEDLINE
- Odds Ratio
- Randomized Controlled Trials as Topic
- Thymosin
(immunology, therapeutic use)
- Transaminases
(analysis)
- Treatment Outcome
|