Pre-operative serum levels of sialyl Tn antigen predict liver metastasis and poor prognosis in patients with gastric cancer.

Abstract

AIMS:

To clarify the prognostic value of preoperative serum levels of sialyl Tn antigen (STN) for survival of gastric cancer patients.

METHODS:

Pre-operative serum levels of STN, sialyl Lewis(a)antigen (CA19-9) and carcinoembryonic antigen (CEA) were examined in 180 patients who underwent resection of gastric cancer. Patients were divided into high and low antigen groups on the basis of a selected diagnostic-based cut-off value. Correlation between high antigen serum levels, established clinicopathologic factors and prognosis was examined by univariate and multivariate analysis.

RESULTS:

Twenty-eight patients (15.6%) were classified as high STN; 37 (20.6%) as high CA19-9; and 33 (18.3%) as high CEA. The survival time of the high STN, CA19-9 or CEA group was shorter than that of the respective low-antigen group (P<0.0001, P=0.0008 or P=0.0002, respectively). Patients with stage III/IV tumours with high STN had a shorter survival time that those with low STN (P=0.0004). Cox's regression with multiple covariates showed that high serum STN is an independent factor predicting a worse outcome in gastric cancer patients. Multiple logistic regression analysis revealed that high serum STN is an independent predictor for the development of liver metastasis.

CONCLUSIONS:

Pre-operative high serum levels of STN predict both liver metastasis and poor prognosis after resection for gastric cancer.

• Authors: T Nakagoe, T Sawai, T Tsuji, M Jibiki, A Nanashima, H Yamaguchi, T Yasutake, H Ayabe, K Arisawa, H Ishikawa
• Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (Eur J Surg Oncol) Vol. 27 Issue 8 Pg. 731-9 (Dec 2001) ISSN: 0748-7983 [Print] England
• PMID: 11735169 (Publication Type: Journal Article)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• sialosyl-Tn antigen

Topics

• Aged
• Antigens, Tumor-Associated, Carbohydrate (analysis)
• Biomarkers, Tumor (analysis)
• Female
• Humans
• Liver Neoplasms (secondary)
• Male
• Middle Aged
• Predictive Value of Tests
• Prognosis
• Prospective Studies
• Reference Values
• Stomach Neoplasms (pathology, surgery)
• Survival Analysis