Retrograde enhancement of memory by mild flurothyl treatment in the chick.

Abstract

Strong flurothyl treatment (1.7% v/v for 8 min) produces retrograde amnesia in chicks when administered as long as 24 hr after one-trial avoidance training with a strongly aversive stimulus. Mild flurothyl treatment (0.2% v/v for 8 min) produced retrograde enhancement when administered as long as 16 min after similar training with a moderately aversive stimulus. The moderate training followed by mild flurothyl treatment enhanced 24-hr retention to the level found after strong training alone. Enhanced retention persisted for at least 72 hr; nonspecific performance effects faded within 48 hr. The predominant dose-dependent and time-dependent enhancement effect of mild flurothyl treatment is interpreted as improved memory consolidation.

• Authors: A Cherkin, R O Meinecke, M W Garman
• Journal: Physiology & behavior (Physiol Behav) Vol. 14 Issue 2 Pg. 151-8 (Feb 1975) ISSN: 0031-9384 [Print] United States
• PMID: 1172242 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Flurothyl

Topics

• Amnesia (chemically induced)
• Amnesia, Retrograde (chemically induced)
• Animals
• Animals, Newborn
• Avoidance Learning (drug effects)
• Chickens
• Conditioning, Psychological (drug effects)
• Dose-Response Relationship, Drug
• Flurothyl (pharmacology)
• Humans
• Male
• Memory (drug effects)
• Time Factors