Second transplantation with CD34+ blood cells from an HLA-mismatched related donor after engraftment failure of transplanted cord blood cells.

Abstract

Unrelated cord blood transplantation (CBT) has been worldwide for bone marrow reconstitution. CBT is associated with a high frequency of engraftment failure and rejection due to a small dose of graft cells. In cases of engraftment failure or rejection following unrelated CBT, retransplantation from the original donors is impossible. We report a successful transplantation with CD34+ blood cells selected from a 2-loci HLA-mismatched mother to a child with acute monocytic leukemia after engraftment failure of the primary CBT. Selected CD34+ blood cell transplantation is a useful approach for retransplantation in the setting of engraftment failure.

• Authors: H Ohta, J Y Kim, A Sawada, S Tokimasa, H Fujisaki, Y Matsuda, Y Osugi, J Hara
• Journal: International journal of hematology (Int J Hematol) Vol. 74 Issue 3 Pg. 338-41 (Oct 2001) ISSN: 0925-5710 [Print] Japan
• PMID: 11721973 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, CD34

Topics

• Adult
• Antigens, CD34 (analysis)
• Blood Cells (cytology, immunology, transplantation)
• Disease-Free Survival
• Female
• Fetal Blood (cytology)
• Graft Survival
• Hematopoietic Stem Cell Transplantation
• Histocompatibility
• Histocompatibility Testing
• Humans
• Infant, Newborn
• Leukemia, Monocytic, Acute (therapy)
• Male