Radioguidance for nonpalpable primary lesions and sentinel lymph node(s).

Abstract

BACKGROUND:

Radioguided surgery can also be used for the simultaneous guidance to a nonpalpable primary tumor and sentinel lymph nodes.

METHODS:

Retrospective review of a prospective database. The surgeon used a gamma probe for guidance to an iodine-125 labeled titanium seed at the primary lesion and technetium-99 labeled sulfur colloid at the sentinel lymph node.

RESULTS:

Forty-three patients with nonpalpable breast carcinoma underwent dual isotope radioguided surgery. The radioactive seed and primary lesion were retrieved in the first excision in all 44 patients (100%). Eleven patients (25%) had pathologically involved margins. Sentinel lymph node mapping was successful in 42 patients (98%). A mean of 2.4 sentinel nodes were excised and metastatic carcinoma was present in four patients (10%).

CONCLUSIONS:

Dual isotopes can be effectively used in breast cancer patients for simultaneous radioguidance to both a nonpalpable primary lesion and sentinel lymph node and allows for improved logistics.

• Authors: R J Gray, R Giuliano, E L Dauway, C E Cox, D S Reintgen
• Journal: American journal of surgery (Am J Surg) Vol. 182 Issue 4 Pg. 404-6 (Oct 2001) ISSN: 0002-9610 [Print] United States
• PMID: 11720680 (Publication Type: Journal Article)

Chemical References

• Iodine Radioisotopes
• Technetium Tc 99m Sulfur Colloid

Topics

• Breast Neoplasms (diagnostic imaging, pathology, surgery)
• Female
• Humans
• Iodine Radioisotopes
• Lymph Node Excision
• Lymph Nodes (diagnostic imaging)
• Lymphatic Metastasis (diagnostic imaging)
• Radionuclide Imaging
• Retrospective Studies
• Sentinel Lymph Node Biopsy
• Technetium Tc 99m Sulfur Colloid