Prevention of anterior glottic restenosis in a canine model with topical mitomycin-C.

Abstract

To develop a model for recurrent anterior glottic stenosis and to test the efficacy of topical mitomycin-C in preventing restenosis, we induced anterior glottic stenosis with a CO2 laser in 5 dogs. In 3 dogs, recurrence was established after surgical lysis. Subsequently, the 3 dogs received a single topical 3-minute treatment with a 1% solution of mitomycin-C after a second surgical lysis. In a parallel experiment, the other 2 dogs received a single topical 3-minute treatment with a 1% solution of mitomycin-C after the initial surgical lysis. An anterior glottic web was induced in all 5 dogs with the CO2 laser. The 3 dogs experienced restenosis at the anterior glottis after surgical lysis alone. Mitomycin-C prevented anterior glottic restenosis in 2 of the 3 dogs treated twice and in both of the dogs treated once (p = .02). We conclude that a recurrent stenosis of the anterior glottis may be induced reproducibly in the canine model with the CO2 laser. Application of topical mitomycin-C after lysis of an anterior glottic stenosis produces a statistically significant reduction in the rate of restenosis as compared to surgical lysis alone.

• Authors: J E Spector, J A Werkhaven, N C Spector, S Huang, D Sanders, L Reinisch
• Journal: The Annals of otology, rhinology, and laryngology (Ann Otol Rhinol Laryngol) Vol. 110 Issue 11 Pg. 1007-10 (Nov 2001) ISSN: 0003-4894 [Print] United States
• PMID: 11713909 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Mitomycin

Topics

• Administration, Topical
• Animals
• Antibiotics, Antineoplastic (therapeutic use)
• Disease Models, Animal
• Dogs
• Glottis
• Laryngostenosis (prevention & control, surgery)
• Mitomycin (therapeutic use)
• Postoperative Complications (prevention & control)
• Recurrence