Macrophage Stimulator beta-(1-->3)-D-carboxymethylglucan improves the efficiency of chemotherapy of Lewis lung carcinoma.

Abstract

We studied the effect of macrophage stimulator water-soluble beta-(1-->3)-D-carboxymethylglucan on the efficiency of cyclophosphamide chemotherapy in Lewis lung carcinoma. Cyclophosphamide inhibited the growth of primary tumor nodes by 57%. The preparation possessed pronounced antimetastatic activity: metastases were found in 40.9% animals. Combination therapy with cyclophosphamide and (1-->3)-beta;-D-glucan inhibited the growth of intramuscular tumors by 75-89% and reduced the incidence of metastases into the lungs by 92-94%. The therapeutic effect was most pronounced after simultaneous administration of these preparations: tumor growth was suppressed by 89.3% and metastases were found in only 7.5% animals (vs. 100% in the control). The potentiating effect of beta-(1-->3)-D-carboxymethylglucan is related to accumulation of cysteine proteinase inhibitors in the tumor tissue and plasma, but not to changes in blood cell composition.

• Authors: O V Falameeva, O N Poteryaeva, S Y Zhanaeva, O A Levina, T G Filatova, T A Korolenko, V I Kaledin, I Sandula, G Kogan
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 132 Issue 2 Pg. 787-90 (Aug 2001) ISSN: 0007-4888 [Print] United States
• PMID: 11713568 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Alkylating
• Cst3 protein, mouse
• Csta1 protein, mouse
• Cystatin A
• Cystatin C
• Cystatins
• Glucans
• beta-Glucans
• carboxymethyl-beta-1,3-glucan
• Cyclophosphamide
• Cathepsins
• Cysteine Endopeptidases
• Cathepsin B
• Cathepsin L
• Ctsl protein, mouse

Topics

• Animals
• Antineoplastic Agents, Alkylating (administration & dosage, therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Body Weight (drug effects)
• Carcinoma, Lewis Lung (drug therapy, metabolism, pathology)
• Cathepsin B (analysis)
• Cathepsin L
• Cathepsins (analysis)
• Cyclophosphamide (administration & dosage, therapeutic use)
• Cystatin A
• Cystatin C
• Cystatins (blood)
• Cysteine Endopeptidases
• Drug Synergism
• Glucans (administration & dosage)
• Injections, Intraperitoneal
• Lung Neoplasms (secondary)
• Macrophages (drug effects)
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Neoplasm Transplantation
• beta-Glucans