Abstract | BACKGROUND:
Denileukin diftitox, a fusion protein targeting both malignant and normal activated lymphocytes, has been shown previously to have antipsoriatic activity. However, the ideal dosing regimen for treating psoriasis was not established. OBJECTIVE: METHODS: This was a cohort dose-escalation trial. Patients were administered denileukin diftitox on 3 consecutive days every other week. Patients were evaluated for toxicity, improvement in psoriasis, immunogenicity, and serum levels. RESULTS: Thirty-five patients were treated at 3 dose levels. Eight patients had a 50% decrease or more in Psoriasis Area and Severity Index score from baseline (0/10 at 0.5 microg/kg per day, 1/10 at 1.5 microg/kg per day, and 7/15 at 5 microg/kg per day). Adverse events primarily consisted of constitutional events and skin reactions. CONCLUSIONS: The potential antipsoriatic activity of denileukin diftitox demonstrated in this study was comparable to that observed in other psoriasis studies with this agent. However, this dosing regimen was better tolerated than the dosing regimen used in the last study with denileukin diftitox in psoriasis patients.
|
Authors | A Martin, E Gutierrez, J Muglia, C J McDonald, C Guzzo, A Gottlieb, A Pappert, W T Garland, J Bagel, P Bacha |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 45
Issue 6
Pg. 871-81
(Dec 2001)
ISSN: 0190-9622 [Print] United States |
PMID | 11712032
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Diphtheria Toxin
- Interleukin-2
- Proteins
- Recombinant Fusion Proteins
- denileukin diftitox
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Diphtheria Toxin
- Drug Administration Schedule
- Female
- Humans
- Interleukin-2
- Male
- Middle Aged
- Multicenter Studies as Topic
- Proteins
(administration & dosage, immunology)
- Psoriasis
(drug therapy)
- Recombinant Fusion Proteins
- Safety
|