Antinociceptive effect of the novel compound OT-7100 in a diabetic neuropathy model.

Abstract	We previously reported that OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-alpha]pyrimidine) had antinociceptive potency in various animal models. To further characterize this compound, the present study examined the effects of OT-7100 on mechanical hyperalgesia and motor nerve conduction velocity in streptozotocin-induced diabetic rats. OT-7100 significantly increased the nociceptive threshold in the diabetic rat in a dose-dependent manner. Gabapentin (anticonvulsant agent) and insulin strongly increased the nociceptive threshold but gabapentin increased it above normal levels. An aldose reductase inhibitor slightly increased the nociceptive threshold at a high dose. We also measured glucose levels and motor nerve conduction velocity in OT-7100-treated rats. Insulin decreased glucose levels but OT-7100 had no effect on glucose levels or on motor nerve conduction velocity. These results suggest that OT-7100 alleviates hyperalgesia in a diabetic neuropathy model in a different manner from gabapentin or aldose reductase inhibitor and may be a new treatment for the pain associated with peripheral nerve injury.
Authors	S Miki, N Yoshinaga, T Iwamoto, T Yasuda, S Sato
Journal	European journal of pharmacology (Eur J Pharmacol) Vol. 430 Issue 2-3 Pg. 229-34 (Nov 02 2001) ISSN: 0014-2999 [Print] Netherlands
PMID	11711035 (Publication Type: Journal Article)
Chemical References	Acetates Amines Analgesics Cyclohexanecarboxylic Acids Insulin OT 7100 Pyrazoles Pyrimidines gamma-Aminobutyric Acid Gabapentin Glucose
Topics	Acetates (pharmacology) Amines Analgesics (pharmacology) Animals Cyclohexanecarboxylic Acids Diabetic Neuropathies (complications, metabolism, physiopathology) Disease Models, Animal Dose-Response Relationship, Drug Gabapentin Glucose (metabolism) Hyperalgesia (etiology, prevention & control) Insulin (pharmacology) Male Motor Neurons (drug effects, physiology) Neural Conduction (drug effects) Pain Threshold (drug effects) Pyrazoles (pharmacology) Pyrimidines (pharmacology) Rats Rats, Sprague-Dawley Time Factors gamma-Aminobutyric Acid

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