Abstract |
The effects of NG-nitro-L-arginine (L-NNA) on blood pressure of various strains of spontaneously hypertensive rats were studied. Blood pressure of the rats was higher in the order of WKY, SHR, SHRSP, M-SHRSP. L-NNA caused an elevation of the blood pressure, which was greatest in SHR and smallest in WKY and M-SHRSP. Endothelium-dependent relaxation of aortae by acetylcholine was greatest in preparations from WKY and it decreased as the blood pressure of rats increased. Phenylephrine (higher than 10(-6) mg/kg) caused an elevation of the blood pressure, which was greatest in SHR and smallest in M-SHRSP. It was suggested that L-NNA elevated blood pressure by inhibiting the basal or flow-induced release of nitric oxide from the endothelium that is causing a reduction in vascular smooth muscle tone. The smaller effect of L-NNA in WKY was due to weak smooth muscle tone, while the smaller effect in SHRSP and M-SHRSP is due to impaired function of endothelium.
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Authors | K Yamamoto, K Shimamura, F Sekiguchi, S Sunano |
Journal | Clinical and experimental hypertension (New York, N.Y. : 1993)
(Clin Exp Hypertens)
Vol. 23
Issue 7
Pg. 533-44
(Oct 2001)
ISSN: 1064-1963 [Print] England |
PMID | 11710755
(Publication Type: Journal Article)
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Chemical References |
- Enzyme Inhibitors
- Vasoconstrictor Agents
- Phenylephrine
- Nitroarginine
- Nitric Oxide
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Topics |
- Animals
- Blood Pressure
(drug effects)
- Body Weight
- Endothelium, Vascular
(drug effects, physiology)
- Enzyme Inhibitors
(pharmacology)
- Heart Rate
(drug effects)
- Nitric Oxide
(metabolism)
- Nitroarginine
(pharmacology)
- Phenylephrine
(pharmacology)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Species Specificity
- Vasoconstrictor Agents
(pharmacology)
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