Abstract |
A weekly HAI therapy ( CPT-11 80 mg, MMC 4 mg, degradable starch microsphere (DSM) 600 mg) was given to a patient with sigmoid colon cancer and multiple liver metastasis (H3) who had been taking tegafur 300 mg/day and 5-FU 750 mg HAI/week, which resulted in PD. This therapy was carried out on an outpatient basis with minimum side effects (< grade 2). After 8 weeks, the tumor marker dropped to one tenth and the liver metastasis decreased in size (PR). The time courses of the concentrations of CPT-11, SN-38 and SN-38G were determined by drawing blood after HAI with or without DSM. The Cmax and AUC inf. of SN-38 at HAI without DSM were 17 ng/ml and 90.55 ng/h/ml, respectively, which was comparable to that at i.v. administration. The Cmax and AUC inf. of SN-38 at HAI with DSM were 12 ng/ml and 129.19 ng/h/ml, respectively, implying that DSM might have an enhancing effect on CPT-11 due to stasis of the hepatic artery that slows the conversion of CPT-11 to SN-38 resulting in a longer existence of SN-38.
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Authors | M Yukawa, H Ishikawa, T Nakayama, S Oshima, Y Katsumoto, J Furukawa, F Sue, M Inoue |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 28
Issue 11
Pg. 1763-7
(Oct 2001)
ISSN: 0385-0684 [Print] Japan |
PMID | 11708029
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- degradable starch microspheres
- Irinotecan
- Starch
- Fluorouracil
- Camptothecin
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Camptothecin
(administration & dosage, analogs & derivatives, blood)
- Drug Administration Schedule
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Infusions, Intra-Arterial
- Irinotecan
- Liver Neoplasms
(drug therapy, secondary)
- Middle Aged
- Sigmoid Neoplasms
(pathology)
- Starch
(administration & dosage)
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