Functions of BRCA1 and BRCA2 in the biological response to DNA damage.

Abstract

Inheritance of one defective copy of either of the two breast-cancer-susceptibility genes, BRCA1 and BRCA2, predisposes individuals to breast, ovarian and other cancers. Both genes encode very large protein products; these bear little resemblance to one another or to other known proteins, and their precise biological functions remain uncertain. Recent studies reveal that the BRCA proteins are required for maintenance of chromosomal stability in mammalian cells and function in the biological response to DNA damage. The new work suggests that, although the phenotypic consequences of their disruption are similar, BRCA1 and BRCA2 play distinct roles in the mechanisms that lead to the repair of DNA double-strand breaks.

• Authors: A R Venkitaraman
• Journal: Journal of cell science (J Cell Sci) Vol. 114 Issue Pt 20 Pg. 3591-8 (Oct 2001) ISSN: 0021-9533 [Print] England
• PMID: 11707511 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• BRCA1 Protein
• BRCA2 Protein
• Chromatin
• DNA-Binding Proteins
• DNA
• RAD51 protein, human
• Rad51 Recombinase

Topics

• Animals
• BRCA1 Protein (genetics, physiology)
• BRCA2 Protein (genetics, physiology)
• Breast Neoplasms (genetics)
• Chromatin (metabolism)
• DNA (metabolism)
• DNA Damage
• DNA Repair
• DNA-Binding Proteins (metabolism)
• Female
• Humans
• Rad51 Recombinase
• Transcription, Genetic