Abstract | OBJECTIVE: DESIGN: Association and linkage study. SETTING: Population material collected for case and family studies in endometriosis. PATIENT(S): INTERVENTION(S): Association with the GALT gene investigated by genotyping 85 affected women and 213 unrelated control women and a scan for linkage to chromosome 9 in 205 women from 64 families with endometriosis. MAIN OUTCOME MEASURE(S): Multipoint parametric lod scores and frequency of alleles. RESULT(S): There was no significant difference in allele frequency for the N314D polymorphism in patients compared with control subjects. No evidence for linkage was found to chromosome 9p, where the GALT gene resides. CONCLUSION(S): The experiments reported herein provide no evidence supporting involvement of the GALT locus in the development of endometriosis.
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Authors | H Stefansson, A Einarsdottir, R T Geirsson, K Jonsdottir, G Sverrisdottir, V G Gudnadottir, S Gunnarsdottir, A Manolescu, J Gulcher, K Stefansson |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 76
Issue 5
Pg. 1019-22
(Nov 2001)
ISSN: 0015-0282 [Print] United States |
PMID | 11704127
(Publication Type: Journal Article)
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Chemical References |
- UTP-Hexose-1-Phosphate Uridylyltransferase
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Topics |
- Chromosome Mapping
- Chromosomes, Human, Pair 9
(genetics)
- Endometriosis
(genetics)
- Female
- Genetic Linkage
- Heterozygote
- Humans
- Lod Score
- Microsatellite Repeats
- Polymorphism, Genetic
- Reference Values
- UTP-Hexose-1-Phosphate Uridylyltransferase
(genetics)
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