Abstract | BACKGROUND: OBJECTIVES: METHODS: A single 24-h application of 5-10 g (median 6.75) of EMLA was given to 10 patients with painful leg ulcers measuring 50-100 cm2. Venous blood samples, drawn between 0.5 and 27 h after cream application, were analysed by gas chromatography using a nitrogen-sensitive detector. RESULTS: The peak plasma levels were in the range 185-705 ng mL(-1) and 62-277 ng mL(-1) for lignocaine and prilocaine, respectively, and were observed 2-4 h (in one patient 6-8 h) after application. The peak plasma concentration of lignocaine, but not of prilocaine, increased significantly with increasing dose. The cream was well tolerated by the patients. CONCLUSIONS: The results indicate that a 24-h application of 5-10 g EMLA results in peak plasma concentrations of the two local anaesthetics, which combined are less than one-fifth of those associated with toxic reactions. The analgesic efficacy of EMLA for the relief of chronic ulcer pain deserves further study.
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Authors | B Stymne, S Lillieborg |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 145
Issue 4
Pg. 530-4
(Oct 2001)
ISSN: 0007-0963 [Print] England |
PMID | 11703277
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anesthetics, Combined
- Anesthetics, Local
- Lidocaine, Prilocaine Drug Combination
- Ointments
- Prilocaine
- Lidocaine
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Topics |
- Aged
- Aged, 80 and over
- Anesthetics, Combined
(administration & dosage, blood, therapeutic use)
- Anesthetics, Local
(administration & dosage, blood, therapeutic use)
- Chronic Disease
- Dose-Response Relationship, Drug
- Female
- Humans
- Leg Ulcer
(blood, drug therapy)
- Lidocaine
(administration & dosage, blood, therapeutic use)
- Lidocaine, Prilocaine Drug Combination
- Male
- Ointments
- Prilocaine
(administration & dosage, blood, therapeutic use)
- Regression Analysis
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