Immunity induced shortly after DNA vaccination of rainbow trout against rhabdoviruses protects against heterologous virus but not against bacterial pathogens.

Abstract	It was recently reported that DNA vaccination of rainbow trout fingerlings against viral hemorrhagic septicaemia virus (VHSV) induced protection within 8 days after intramuscular injection of plasmid DNA. In order to analyse the specificity of this early immunity, fish were vaccinated with plasmid DNA encoding the VHSV or the infectious haematopoietic necrosis virus (IHNV) glycoprotein genes and later challenged with homologous or heterologous pathogens. Challenge experiments revealed that immunity established shortly after vaccination was cross-protective between the two viral pathogens whereas no increased survival was found upon challenge with bacterial pathogens. Within two months after vaccination, the cross-protection disappeared while the specific immunity to homologous virus remained high. The early immunity induced by the DNA vaccines thus appeared to involve short-lived non-specific anti-viral defence mechanisms.
Authors	Niels Lorenzen, Ellen Lorenzen, Katja Einer-Jensen, Scott E LaPatra
Journal	Developmental and comparative immunology (Dev Comp Immunol) Vol. 26 Issue 2 Pg. 173-9 (Mar 2002) ISSN: 0145-305X [Print] United States
PMID	11696382 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Vaccines, DNA Viral Vaccines
Topics	Aeromonas (growth & development, immunology) Amino Acid Sequence Animals Fish Diseases (immunology, prevention & control, virology) Gram-Negative Bacterial Infections (immunology, microbiology) Infectious hematopoietic necrosis virus (genetics, growth & development, immunology) Logistic Models Molecular Sequence Data Novirhabdovirus (genetics, growth & development, immunology) Oncorhynchus mykiss (immunology) Rhabdoviridae Infections (immunology, prevention & control, veterinary, virology) Sequence Alignment Sequence Homology, Amino Acid Vaccination (veterinary) Vaccines, DNA (immunology, standards) Viral Vaccines (immunology) Yersinia (growth & development, immunology) Yersinia Infections (immunology, microbiology)

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