Macromolecular complexes: SMN--the master assembler.

Abstract

Recent studies indicate that the protein affected in spinal muscular atrophy, SMN, plays a role in the assembly of a number of macromolecular complexes that function in the nucleus, interacting with its partner proteins via their arginine- and glycine-rich domains.

• Authors: M P Terns, R M Terns
• Journal: Current biology : CB (Curr Biol) Vol. 11 Issue 21 Pg. R862-4 (Oct 30 2001) ISSN: 0960-9822 [Print] England
• PMID: 11696342 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Cyclic AMP Response Element-Binding Protein
• Nerve Tissue Proteins
• RNA-Binding Proteins
• Ribonucleoproteins, Small Nuclear
• SMN Complex Proteins

Topics

• Coiled Bodies (metabolism)
• Cyclic AMP Response Element-Binding Protein
• Muscular Atrophy, Spinal (etiology)
• Nerve Tissue Proteins (metabolism)
• Protein Binding
• RNA Splicing
• RNA-Binding Proteins
• Ribonucleoproteins, Small Nuclear (metabolism)
• Ribosomes (metabolism)
• SMN Complex Proteins
• Spliceosomes (metabolism)
• Transcription, Genetic