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The use of sweet rolls fortified with iron bis-glycinate chelate in the prevention of iron deficiency anemia in preschool children.

Abstract
The effectiveness of bread fortified with iron bis-glycinate chelate for the control of iron deficiency and iron deficiency anemia was evaluated in 89 preschool children from families of low socioeconomic level attending 2 day nurseries of the Sao Paulo City Council. During the intervention's time of 6 months the children received besides their usual center's diet, a daily supplement of two sweet rolls fortified with 2 mg each of iron from the chelate for a total daily iron intake of 4 mg. After six months of intervention there was a significant decrease in the prevalence of iron deficiency anemia from 62 to 22%. There was a mean hemoglobin improvement of 1.1 g/dL, and in children with initial hemoglobin levels < 11 g/dL the mean increase in hemoglobin was 1.42 g/dL. The total mean plasma ferritin values increased from 11.34 to 20.2 micrograms/L, and in those children originally iron depleted the ferritin values normalized. A significant increase in the "z" score for weight/height was also observed. We concluded that the use of sweet rolls fortified with 2 mg of iron from the bis-glycinate chelate is highly effective for the control of iron deficiency and iron deficiency anemia in young children.
AuthorsE Giorgini, M Fisberg, R A De Paula, A M Ferreira, J Valle, J A Braga
JournalArchivos latinoamericanos de nutricion (Arch Latinoam Nutr) Vol. 51 Issue 1 Suppl 1 Pg. 48-53 (Mar 2001) ISSN: 0004-0622 [Print] Venezuela
PMID11688082 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Ferrous Compounds
  • Hemoglobins
  • Iron Chelating Agents
  • bis-glycino iron II
  • Ferritins
  • Glycine
Topics
  • Anemia, Iron-Deficiency (epidemiology, prevention & control)
  • Anthropometry
  • Brazil (epidemiology)
  • Bread
  • Child
  • Child, Preschool
  • Female
  • Ferritins (blood)
  • Ferrous Compounds (therapeutic use)
  • Food, Fortified
  • Glycine (analogs & derivatives, therapeutic use)
  • Hemoglobins (analysis)
  • Humans
  • Iron Chelating Agents (therapeutic use)
  • Iron Deficiencies
  • Male
  • Prevalence
  • Treatment Outcome

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