Abstract |
UV light exerts hazardous effects such as induction of skin cancer and premature skin aging. In this study we evaluated an assumptive anti-inflammatory effect of the nonsedative histamine H1-receptor antagonist, mizolastine, on UV-induced acute sunburn reaction. Therefore, a clinical, randomized, double-blind, four-arm, crossover study was conducted in healthy young female volunteers (skin type II) comparing the UV sensitivity under mizolastine, acetyl- salicylic acid (ASA), indomethacin or a mizolastine/ASA combination. Moreover, HaCaT keratinocytes were incubated with mizolastine under various UV treatment modalities in vitro to study its effect on the release of inflammatory cytokines, i.e. interleukin (IL)-1 alpha, IL-6 and tumor necrosis factor alpha ( TNF-alpha). All three drugs were effective in suppressing the UVB-, UVA- and combined UVA/UVB- erythema. However, the strongest effects were observed using the combined treatment with both 250 mg ASA and 10 mg mizolastine. An inhibitory effect in vitro of 10 nM mizolastine upon UV-induced cytokine release from HaCaT keratinocytes was observed for IL-1 alpha at 24 h after 10 J/cm2 UVA1, for IL-6 at 48 h after 10 J/cm2 UVA1 and 30 mJ/cm2 UVB, and also for TNF-alpha at 4 h after 10 J/cm2 UVA, 10 J/cm2 UVA1 and 30 mJ/cm2 UVB, respectively. The combination of mizolastine and ASA can be strongly recommended as a protective measure against UV erythema development with a lower unwanted side effect profile than that of the hitherto treatment modality, i.e. indomethacin.
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Authors | J U Grundmann, R Böckelmann, B Bonnekoh, H P Gollnick |
Journal | Photochemistry and photobiology
(Photochem Photobiol)
Vol. 74
Issue 4
Pg. 587-92
(Oct 2001)
ISSN: 0031-8655 [Print] United States |
PMID | 11683039
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Benzimidazoles
- Drug Combinations
- Histamine H1 Antagonists
- Interleukin-1
- Interleukin-6
- Tumor Necrosis Factor-alpha
- mizolastine
- Aspirin
- Indomethacin
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Topics |
- Adolescent
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Aspirin
(pharmacology)
- Benzimidazoles
(pharmacology)
- Cells, Cultured
(metabolism, radiation effects)
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- Double-Blind Method
- Drug Combinations
- Erythema
(etiology)
- Female
- Histamine H1 Antagonists
(pharmacology)
- Humans
- Indomethacin
(pharmacology)
- Interleukin-1
(analysis, metabolism)
- Interleukin-6
(analysis, metabolism)
- Keratinocytes
(drug effects, metabolism, radiation effects)
- Skin
(drug effects, metabolism, radiation effects)
- Sunburn
(etiology)
- Time Factors
- Tumor Necrosis Factor-alpha
(analysis, metabolism)
- Ultraviolet Rays
(adverse effects)
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