Abstract | BACKGROUND: METHOD: Participants in the study were inpatients or outpatients with a DSM-IV diagnosis of bipolar or schizoaffective disorder. Baseline psychopathology was evaluated with the Brief Psychiatric Rating Scale (BPRS), the Young Mania Rating Scale (YMRS), and the Hamilton Rating Scale for Depression (HAM-D). Involuntary movements were rated with the Simpson-Angus Neurologic Rating Scale. Quetiapine was added on an open-label basis and increased to optimum clinical dosage. Psychopathology and Abnormal Involuntary Movement Scale ratings were repeated weekly for the first 4 weeks and then again at weeks 8 and 12. RESULTS: CONCLUSION: Although limited by its small size, open-label design, and relative gender homogeneity, this study suggests that quetiapine therapy may be useful in the treatment of individuals with serious mood disorders who are suboptimally responsive to mood stabilizers alone. These preliminary findings should be explored in larger, controlled trials.
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Authors | M Sajatovic, D W Brescan, D E Perez, S K DiGiovanni, H Hattab, J B Ray, C R Bingham |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 62
Issue 9
Pg. 728-32
(Sep 2001)
ISSN: 0160-6689 [Print] United States |
PMID | 11681770
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antipsychotic Agents
- Dibenzothiazepines
- Quetiapine Fumarate
- Valproic Acid
- Lithium
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Topics |
- Adult
- Aged
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Bipolar Disorder
(diagnosis, drug therapy)
- Brief Psychiatric Rating Scale
(statistics & numerical data)
- Dibenzothiazepines
(adverse effects, therapeutic use)
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Hospitalization
- Humans
- Lithium
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Prospective Studies
- Psychiatric Status Rating Scales
(statistics & numerical data)
- Psychotic Disorders
(diagnosis, drug therapy)
- Quetiapine Fumarate
- Severity of Illness Index
- Treatment Outcome
- Valproic Acid
(adverse effects, therapeutic use)
- Weight Gain
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